Differences in protection against previous infection or vaccination against infection with Omicron BA.4/5 or BA.2

In a recent study posted to the medRxiv* preprint server, researchers examined the differences in vaccination- and prior infection-induced immunities against the Omicron BA.2 and BA.4/5 subvariants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Higher risk of SARS-CoV-2 Omicron BA.4/5 infection than BA.2 infection after previous BA.1 infection, The Netherlands, May 2 to … Read more

Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cell models

In a recent study posted to the bioRxiv* preprint server, researchers in Australia investigated the molecular mechanisms of the pulmonary and cardiac complications caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using human stem cell-derived heart and lung cells. Study: Parallel use of pluripotent lung and heart models of human stem cells … Read more

First data on the Omicron BA.4/5 combination vaccine from Pfizer-BioNTech

In a recent study posted to the bioRxiv* preprint server, researchers from Germany and the United States analyzed the association between exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4/BA.5 spike glycoprotein and pan-Omicron neutralization. Study: Exposure to BA.4/BA.5 Spike glycoprotein stimulates pan-Omicron neutralization in vaccine-experienced humans and mice. Image Credit: Naeblys/Shutterstock Background … Read more

Long-term follow-up of young people with COVID-19 vaccine myocarditis

In a recent study published in Immunity, researchers examined a comprehensive range of outcomes in patients diagnosed with myocarditis after vaccination against coronavirus disease 2019 (COVID-19) in the United States (US). They followed up these adolescents and young male patients after receiving a messenger ribonucleic acid (mRNA) platform-based COVID-19 vaccine for a minimum of 90 … Read more

Population-wide cohort study detects increase in major arterial and venous thrombotic events immediately after COVID-19 diagnosis

In a recent study published in CirculationResearchers examined the link between coronavirus disease 2019 (COVID-19) and vascular thrombotic events using a population-wide cohort study in England and Wales. Study: Association of COVID-19 with severe arterial and venous thrombotic disease: a population-wide cohort study of 48 million adults in England and Wales. Image credit: MattLphotography/Shutterstock Background … Read more

Researchers report development of self-assembled trimeric RBD subunit vaccine that can prevent SARS-CoV-2 infection

Since the emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, several genomic mutations have been detected. For example, the currently dominantly circulating SARS-CoV-2 Omicron variant contains many mutations responsible for its increased virulence and transmissibility compared to the original SARS-CoV-2 strain. Study: A proprietary … Read more

Clinical and epidemiological features of SARS-CoV-2 in companion animals

In a recent study posted to the Research Square* preprint server, researchers examined the clinical and epidemiological features of coronavirus disease 2019 (COVID-19) in dogs and cats. Numerous beneficial effects of pet ownership, including mental health benefits, have been scientifically established. Companion animals account for 60% of all animals reported to the World Organization for … Read more

Needle-free jet injection of new COVID-19 DNA vaccine shows promise in animal model

In a recent study posted to the bioRxiv*server, researchers from the United States Army Medical Research Institute of Infectious Diseases evaluated the immunogenicity of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) deoxyribonucleic acid (DNA) vaccine, nCOV-S(JET), in rhesus monkeys. A previous evaluation of this coronavirus disease 2019 (COVID-19) DNA vaccine targeting the SARS-CoV-2 spike … Read more

An improved COVID-19 vaccine shows promise against Omicron in experimental models

In a recent study published in the journal Science Translational MedicineResearchers in the United States have designed a bivalent vaccine against coronavirus disease 2019 (COVID-19) on the messenger ribonucleic acid (mRNA) platform. This mRNA lipid nanoparticle vaccine (LNP) encoded a full-length nucleocapsid (N) protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ancestral strain … Read more

A year later, 40% of patients with COVID pneumonia still had lung problems

A recent study published in the journal Respiratory Exam found impaired lung function and shortness of breath in survivors of severe COVID-19 pneumonia one year after infection. Meanwhile, many COVID-19 patients developed fibrotic-like sequelae as an aftermath of the infection-associated mild or severe pneumonia. ​​​​​​​Study: Lung function and radiologic findings 1 year after COVID-19: a … Read more