Monkeypox virus structural analysis to guide broad antiviral drug development

In a recent study posted to the bioRxiv* preprint server, researchers investigated the crystalline structure of monkeypox (MPX) virus (MPXV) and the complex of VP39, a 2′-O-RNA methyltransferase (MTase) and sinefungin, a pan-MTase inhibitor. Study: The structure of the monkeypox virus 2′-O-ribose methyltransferase VP39 in complex with sinefungin provides the basis for the design of … Read more

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

Scientists have identified lucidic acid A, one of the bioactive compounds of Ganoderma lucidum, as a potential inhibitor of host cell entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study was recently published in the journal Food and Chemical Toxicology. Study: Lucidic acid A inhibits binding of the hACE2 receptor with spike protein … Read more

Primary vaccinations and boosters effective in reducing the severity of COVID-19 during Delta and Omicron predominance

In a recent study published in the Journal of the American Medical AssociationResearchers analyzed the 2019 coronavirus disease (COVID-19) vaccination and surveillance data to understand the effect of primary vaccinations, boosters, and previous severe acute respiratory syndrome coronavirus 2 infections (SARS-CoV-2) on severe COVID-19 outcomes and subsequent infections. Study: Association of primary and booster vaccination … Read more

Wastewater epidemiology can guide local clinical decisions about circulating viruses

The findings of a new study posted to the medRxiv* preprint server depicted that wastewater-based epidemiology (WBE) can provide information about the circulating respiratory viruses in a community. This method not only saves time and money, but can also aid in appropriate clinical decision-making, behavioral change, and public health interventions. Research: Wastewater monitoring of human … Read more

Food, vaccines, bacteria and viruses can all prepare our immune system to attack SARS-CoV-2

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the ongoing coronavirus disease pandemic 2019 (COVID-19), mainly causes mild to moderate upper respiratory tract disease. However, some individuals with COVID-19 develop serious infections and require hospitalization. Study: reaction of SARS-CoV-2 antibodies with other pathogens, vaccines and food antigens. Image Credit: Peddalanka Ramesh Babu / … Read more

Differences in protection against previous infection or vaccination against infection with Omicron BA.4/5 or BA.2

In a recent study posted to the medRxiv* preprint server, researchers examined the differences in vaccination- and prior infection-induced immunities against the Omicron BA.2 and BA.4/5 subvariants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Higher risk of SARS-CoV-2 Omicron BA.4/5 infection than BA.2 infection after previous BA.1 infection, The Netherlands, May 2 to … Read more

Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cell models

In a recent study posted to the bioRxiv* preprint server, researchers in Australia investigated the molecular mechanisms of the pulmonary and cardiac complications caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using human stem cell-derived heart and lung cells. Study: Parallel use of pluripotent lung and heart models of human stem cells … Read more

First data on the Omicron BA.4/5 combination vaccine from Pfizer-BioNTech

In a recent study posted to the bioRxiv* preprint server, researchers from Germany and the United States analyzed the association between exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4/BA.5 spike glycoprotein and pan-Omicron neutralization. Study: Exposure to BA.4/BA.5 Spike glycoprotein stimulates pan-Omicron neutralization in vaccine-experienced humans and mice. Image Credit: Naeblys/Shutterstock Background … Read more

Researchers examine neurological manifestations in tall COVID patients

In a recent study published in naturopathyresearchers assessed the long-term neurological consequences in the post-acute phase of coronavirus disease 2019 (COVID-19) or long-term COVD. Study: Long-term neurological outcomes of COVID-19. Image Credit: Starocean/Shutterstock Long COVID-19 refers to the spectrum of post-acute COVID-19 consequences with various extrapulmonary manifestations, including neurological abnormalities. Most studies of long-term COVID-associated … Read more

Scientists find novel coronavirus in Russian bats that can evade immunity from current vaccines

Just as the world is pulling itself out of a pandemic that has brought life to a standstill for more than two years, yet another novel Coronavirus – Khosta-2 – has been found by scientists in Russia, according to a journal PLoS Pathogens. According to the report, scientists have found a group of coronaviruses similar … Read more